Petrov suffering from leukaemia

Pooya

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#1
Aston Villa have announced that midfielder Stiliyan Petrov is suffering from acute leukaemia.

Villa captain Petrov, 32, has made 30 appearances for the club this season in all competitions and most recently featured in Saturday's 3-0 defeat to Arsenal, but reported that he was feeling unwell in the aftermath of the game.

A club statement read: "The Villa board received news today that our long-standing captain Stiliyan Petrov has been diagnosed with acute leukaemia.

"Stiliyan developed a fever following the Arsenal game last Saturday and subsequently underwent tests. Haematology experts confirmed the diagnosis today.

"We expect to learn more about Stiliyan's situation in due course and we have moved quickly to support him and his family. During this time we ask that Stiliyan's privacy is placed ahead of all inquiries and trust that we will share information as we receive it.

"Stiliyan is cherished by many and he will get from Villa every ounce of love and support that we have to help bring this to a positive conclusion."

The announcement brought an immediate outpouring of support for Petrov, with Celtic manager and former Hoops team-mate Neil Lennon among those taking to Twitter.

"Absolutely inconsolable here regarding Stilian," Lennon Tweeted. "He will overcome this like all the other barriers he faced in his life.

"Stilian has the heart of a lion and as part of the Celtic family he deserves all our best wishes and support."

Support poured in for Petrov from his Villa team-mates on Twitter.

Striker Darren Bent said: "Really sad news to hear about our captain Stan Petrov. hopefully he'll be back fighting fit soon. Thoughts are with him and his family. KTF."

Goalkeeper Shay Given tweeted: "In shock about Stiliyan Petrov acute leukaemia but we are all here for him and his family. Please God he makes a full recovery. #prayforstan."

Jermaine Jenas, a former team-mate of Petrov's at Villa, said: "Just saw the news about Stan Petrov one of the nicest guys in football! Thoughts with him and his lovely family."

PFA chairman Gordon Taylor also promised all the help the players' union can provide to Petrov and has written to the Villa skipper to offer his support.

Taylor said: "It's a terrible shock, especially so soon after what has happened to Fabrice [Muamba]. All our thought and hopes with him.

"Stiliyan is a great character, a good leader, and we will give him all the help and support we can.

"Whenever I have met him I have been most impressed by him, he is a great gentleman, we are proud to have him as a PFA member and I just hope that, like Fabrice, he can come through it."

stiliyan-petrov-image-1-246006198.jpg
 

IPride

National Team Player
Oct 18, 2002
5,885
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Toronto, Canada
#2
I hope he recovers..
Had mankind spent 5% of the amount it has spent on global wars in the last 30 years on developing a cure for this fucking disease we would have had 10 different cures by now..
 

Sly

Football Legend
Oct 18, 2002
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#3
The good news is that with good healthcare, leukaemia has a very high survival rate. Most patients become completely cancer free.
 

kasra1930

National Team Player
Dec 30, 2011
5,381
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#4
I hope he recovers..
Had mankind spent 5% of the amount it has spent on global wars in the last 30 years on developing a cure for this fucking disease we would have had 10 different cures by now..
Afarin,Afarin,and Afarin,what a valuable thing you said.....unfortunately this world belong to greedy people,,with criminal attitude,just look at the world around,war,war,war.....
 

kasra1930

National Team Player
Dec 30, 2011
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#5
The good news is that with good healthcare, leukaemia has a very high survival rate. Most patients become completely cancer free.
sly aziz,it depends on the type of leukemia,and bone marrow transplant,but still people die of it,especially if it is in acute phase.....
 

Niloufar

Football Legend
Oct 19, 2002
29,626
23
#6
I hope he recovers..
Had mankind spent 5% of the amount it has spent on global wars in the last 30 years on developing a cure for this fucking disease we would have had 10 different cures by now..
GOLD..

poor guy..hope he recovers..about a year ago, we lost a far family friend here who was only 21 yrs old due to acute Leukomia. hope Petrov recovers from this killer illness..
 

kasra1930

National Team Player
Dec 30, 2011
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#8
Dr, jaan, i dont get it dont these players get blood tested regularly? Leukemia doesnt show up i guess in regular blood tests?
pooya jan,usually they do blood test once a year,but if you are young and your first blood test is normal,then they do every 3 years,...

2)the problem with leukemia is,the signs and symptoms are very non specific,for example,they present to the doctor s office with frequent cold,fatigue,tiredness,frequent infections...first doctors can not diagnose it,because they think ,it is a simple cold,or simple ear infection,but then when patient frequently present to them then,they get suspicious,then they check blood test and then they will find it.
3)in leukemia,what will happen is your white blood cells which are body soldiers,get numerous(normal count is between 5000 to 10,000) in leukemia your white blood cells usually exceed over 100,000...and because they are immature cells,they break down easily in the body,and perticipate in the vessels(sorkhrag),then obstruct the blood flow and this can cause heart attack,stroke,and young patients develop heart attack at age of 25!!!
4)but the major symptoms and signs are,inability to get rid of infection,because the body soldiers are immature,then with a very mild infection,they predisposed to get infections and any simple infection can kill them right away.so most people died of side effects of disease (infections,bleeding,and ect),the same mechanism with HIV,AND AIDS....
5)now treatment is chemotherapy,but with chemo again you will be at risk ok having,infections,bleeding,kidney and liver damage,nerve damage and many many side effects,and still in 50 % of cases you do not cure it.....so in medical term is called remission and recurrence,it means,you feel better after treatment but then few months after you develop symptoms again....
6)but the best treatment is,BONE MARROW TRANSPLANT,but in this kind of treament,you need a sibling or a first degree family to donor his or her bone marrow to you,in other word,their blood antigen match with your blood antigen which is a tough task,and may be in every 200.000 people one can be matched with your blood antigen.
7) bone marrow transplant,is very risky too,and can damage your immune system and people die of infections too,because in this subject,they give some drugs to lower the immune system,for not rejecting the transplant,but on the other hand,these meds,can predispose you to get serious infection and they die of it.
8)any kind of transplant can damage your immune systems,LIVER TRANSPLANT,can produce same symptoms that I mentioned,ABIDAL IS AT RISK OF DYING DUE TO SERIOUS INFECTION AFTER TRANSPLANT.
9)SAME THING HAPPENED TO GEORGE BEST TOO.
 

kasra1930

National Team Player
Dec 30, 2011
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#9
[video=youtube;jyAetFDRpI8]http://www.youtube.com/watch?v=jyAetFDRpI8[/video]

pooya jan,this is a brief video clip about leukemia,this abnormal white blood cells which are cancerous are called BLASTS...............
 

Sly

Football Legend
Oct 18, 2002
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#10
because they are immature cells,they break down easily in the body
Kasra jan, can you elaborate on this please? Why would immature cells break down easily in your body? Because there are a lot of immature cells even in healthy bodies.

4)but the major symptoms and signs are,inability to get rid of infection,because the body soldiers are immature,then with a very mild infection,they predisposed to get infections and any simple infection can kill them right away.so most people died of side effects of disease (infections,bleeding,and ect),the same mechanism with HIV,AND AIDS....
But they should still have effector cells left in their body, eventhough immature cells are numerous? Even immature cells should be able to get activated upon infection and contribute to more effector cells (specially by adjuvant therapy)? I thought one thing Leukaemia patients were gonna avoid, was being in danger by simple infections, unless ofcourse they've used chemodrugs.
 

kasra1930

National Team Player
Dec 30, 2011
5,381
361
#11
[video=youtube;PlFhC1egESI]http://www.youtube.com/watch?v=PlFhC1egESI[/video]

POOYA JAAN I ENCOURAGE YOU SEE THIS VIDEO,IT IS ABOUT HOW THEY DO BONE MARROW TRANSPLANT,VERY INFORMATIVE FOR PEOPLE................
 

kasra1930

National Team Player
Dec 30, 2011
5,381
361
#12
Kasra jan, can you elaborate on this please? Why would immature cells break down easily in your body? Because there are a lot of immature cells even in healthy bodies.



But they should still have effector cells left in their body, eventhough immature cells are numerous? Even immature cells should be able to get activated upon infection and contribute to more effector cells (specially by adjuvant therapy)? I thought one thing Leukaemia patients were gonna avoid, was being in danger by simple infections, unless ofcourse they've used chemodrugs.[/QUOTE

SLY AZIZ:thanks for reply,it seems not only you are expert in soccer but also in medicine too,I like it....
but about your first question:
1)you are absolutely right (as your comment in soccer,)usually our body can have even up to1- 5% or sometimes more immature cells in the circulation(especially in acute infections which your blood needs white blood cells,your bone marrow autonomously make too much immature cells just to fight with infections but never exceeds above 10%...,but the rest 90% function very good,and are mature,but in leukemia,almost 30% or more cells even up to 90% can be immature,so they can not defend..like a immature baby....
2)the immature cells can break down easily,like baby....every cell in the body has a coverage,is called membrane,membrane protects your cells,in immature cells,the membrane,nucleus(the middle part of the cells),are immature,so they can not protect cells easily,so any thing,including fluid,bacteria,virus,foreign bodies can enter easily to the cells and damage the cells and kill them..........it seems your house walls have too much holes on it,if it rains ,whole water comes across your house,due to disabled wall...
3)immature cells can not defend against bacteria,looks like I have just one hand ,can I fight with you, while you have two hands ?of course not,I might fight with you for few minutes but then I am done...............
4)you might have some effector cells in the body,but not enough though,suppose you are 10 then you have to fight with us who are 10000.....
5)adjuvant therapy and chemo,are good options,but unfortunately,when they kill immature cells,they kill,your effector cells too,and that is one of the major one unfavorite side effects of adjuvant therapy,it means,after chemo especially with in the next month watch yourself very carefully,this is the worst time you get infections...
 
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Sly

Football Legend
Oct 18, 2002
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#13
Kasra jan, thanks, it's interesting discussing this with you! Anyways, as far as I know adjuvant therapy (depending on your adjuvant), is being used to stimulate and activate your naive but mature immune cells into effector cells. It's often used after extensive chemotherapy in order to strengthen the patient's immune response against potential infections. So if a leukaemia patient gets his disease because of a naive or immature immune cell, I don't see why a proper adjuvant therapy wouldn't turn his immature cells into mature/activated ones, hence protecting him from infections. Unless ofcourse the source of malignant immune cells are either B or T-lymphocytes which are already specialized for certain specific antigens and would be difficult to protect against any antigen.
 
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kasra1930

National Team Player
Dec 30, 2011
5,381
361
#14
Kasra jan, thanks, it's interesting discussing this with you! Anyways, as far as I know adjuvant therapy (depending on your adjuvant), is being used to stimulate and activate your naive but mature immune cells into effector cells. It's often used after extensive chemotherapy in order to strengthen the patient's immune response against potential infections. So if a leukaemia patient gets his disease because of a naive or immature immune cell, I don't see why a proper adjuvant therapy wouldn't turn his immature cells into mature/activated ones, hence protecting him from infections. Unless ofcourse the source of malignant immune cells are either B or T-lymphocytes which are already specialized for certain specific antigens and would be difficult to protect against any antigen.
good job,sly jan it seems you are very professional.I like your knowledge,are you immunologist or are you in any medical field?what you said it is all correct,but I need to add some more phrases too,as you said,we have 2 different kind of cells,T AND B CELLS,T CELLS protect cells against viruses,fungi and parasites,B cells protect against bacteria,Tcell leukemia is always malignant and very hard to treat,why?because not only T cell protect your body against viruses,parasites and fungi,but also stimulate B cells,so it enable Bcells to function,so T CELL dysfunction=B cell dysfunction.but if you have B cell leukemia,it can respond to therapy better,because your T cell still function...
2)adjuvant therapy are very good,and usually strenthgen your naive cells to the mature cells(but it takes time,normally between 3-6 months),but sometimes,they could also damage your normal healthy cells,as you you know these medications,affect on different phase of cell divisions,(are called MIOSIS,MITOSIS),in DNA,and sometimes they can produce mutations in cells and can convert your healthy cells to cancerous cells,so although sometimes these medications do their great job,but sometimes produces big problems for the normal cells......plus during the phase your naive cells would converte to mature cells(3-6 months period )with in this period due to low mature cells cancerous patients can die of infections...
3)effector cells belong to T-cells,it means if your T,CELL FUNCTION,BUT YOUR B CELL DOES NOT FUNCTION,you are immune against viruses and parasites and fungi,but You are not immune against bacteria,because against bacteria you need B-CELL function,so cancerous patient with B cell leukemia can die of bacterial infection,even though has a good effector cell function...
 
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#15
We're all praying for Petrov just as much as we did for Muamba and his recovery has been remarkable.

Stiliyan has been extremely popular for Villa, likewise in Celtic and I hope the Scottish side hope he gets well soon against St. Johnstone this afternoon like the way Villa did when they lost 4-2 to Chelsea yesterday.
 

Sly

Football Legend
Oct 18, 2002
27,100
264
#17
good job,sly jan it seems you are very professional.I like your knowledge,are you immunologist or are you in any medical field?what you said it is all correct,but I need to add some more phrases too,as you said,we have 2 different kind of cells,T AND B CELLS,T CELLS protect cells against viruses,fungi and parasites,B cells protect against bacteria,Tcell leukemia is always malignant and very hard to treat,why?because not only T cell protect your body against viruses,parasites and fungi,but also stimulate B cells,so it enable Bcells to function,so T CELL dysfunction=B cell dysfunction.but if you have B cell leukemia,it can respond to therapy better,because your T cell still function...
2)adjuvant therapy are very good,and usually strenthgen your naive cells to the mature cells(but it takes time,normally between 3-6 months),but sometimes,they could also damage your normal healthy cells,as you you know these medications,affect on different phase of cell divisions,(are called MIOSIS,MITOSIS),in DNA,and sometimes they can produce mutations in cells and can convert your healthy cells to cancerous cells,so although sometimes these medications do their great job,but sometimes produces big problems for the normal cells......plus during the phase your naive cells would converte to mature cells(3-6 months period )with in this period due to low mature cells cancerous patients can die of infections...
3)effector cells belong to T-cells,it means if your T,CELL FUNCTION,BUT YOUR B CELL DOES NOT FUNCTION,you are immune against viruses and parasites and fungi,but You are not immune against bacteria,because against bacteria you need B-CELL function,so cancerous patient with B cell leukemia can die of bacterial infection,even though has a good effector cell function...
Kasra jan, thanks. I work with Immunology/Immunotherapy. You are also correct about T cells and B cells. However I also have to add that there are different kinds of T cells. One kind is cytotoxic T cell (CD8+) who's job is to kill cancer cells and cells that are infected with viruses (just as you say very correctly). There is also another type which is called T helper cell (CD4+). That is the one who, so to say, orchestrates the defence and produces different signal proteins (cytokines) to help other cells like B cells to engage foreign antigens.

Having said that, in today's science, the different cell types are not as categorised as they were before anymore. Different capabilities are shared among many cell types. For example a lot of the signal proteins produced by T cells upon activation, are also produced by other cells like B cells. All the different cells help eachother in a very complicated way to induce extensive immune respose against antigens. So in many occasions, "depending on the type of the invaded antigen", the lack of functioning of an antigen specific white blood cell, could not matter. Because the other cell types could still get rid of the danger.

B cells are progenitor to cells which produce antibodies. The antibodies can attach to different danger molecules and stop their function. Those danger molecules can be on a bacteria, but they can also be related to viruses or other dangerous molecules coming to our body via food or air for example. There are also other cell types like macrophages, which are specialised to kill bacteria (among their many tasks). They take up the bacteria and digest it inside their body. Then they release signals to other cell types to make them ready. So it's very difficult to put different cells in special categories because they all share a lot of things with each other.

I think using adjuvant therapy is rather bad for leukaemia patients because it will only activate their white blood cells and lead to further expansion of them. Something leukaemia patients, already having a cell expansion, should really avoid. But the bone marrow transplantation is probably what is best for them just as you, very correctly, suggested earlier.
 
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kasra1930

National Team Player
Dec 30, 2011
5,381
361
#18
Kasra jan, thanks. I work with Immunology/Immunotherapy. You are also correct about T cells and B cells. However I also have to add that there are different kinds of T cells. One kind is cytotoxic T cell (CD8+) who's job is to kill cancer cells and cells that are infected with viruses (just as you say very correctly). There is also another type which is called T helper cells (CD4+). Those are the ones who, so to say, orchestrate the defence and produce different signal proteins (cytokines) to help other cells like B cells to engage foreign antigens.

Having said that, in today's science, the different cell types are not as categorised as they were before anymore. Different capabilities are shared among many cell types. For example a lot of the signal proteins produced by T cells upon activation, are also produced by other cells like B cells. All the different cells help eachother in a very complicated way to induce extensive immune respose against antigens. So in many occasions, "depending on the type of the invaded antigen", the lack of functioning of an antigen specific white blood cell, could not matter. Because the other cell types could still get rid of the danger.

B cells are progenitor to cells which produce antibodies. The antibodies can attach to different danger molecules and stop their function. Those danger molecules can be on a bacteria, but they can also be related to viruses or other dangerous molecules coming to our body via food or air for example. There are also other cell types like macrophages, which are specialised to kill bacteria (among their many tasks). They take up the bacteria and digest it inside their body. Then they release signals to other cell types to make them ready.

I think using adjuvant therapy is rather bad for leukaemia patients because it will only activate their white blood cells and lead to further expansion of them. Something leukaemia patients should really avoid. But the bone marrow transplantation is probably what is best for them just as you, very correctly, suggested earlier.
very informative,yes,immunolgy is a great sbject,especially when it comes to the cells,future of medicine is immunotherapy.I congratulate you ,this branch ,you study is future of treatments in medicine.natural killer cells,macrophages,and etc...
actually I am treating most of my patients with immunotherapy medications,like tumor necrosis factors,which actually have revolutionized medicine,they are very useful in cancerous patients and rheumatic diseases,or in other features of autoimmune diseases,like lupus,and some blood disorders like lymphoma.....the only problem is they predispose you to get severe infection,especially tuberculosis,septic shock and etc.....
 

Sly

Football Legend
Oct 18, 2002
27,100
264
#19
very informative,yes,immunolgy is a great sbject,especially when it comes to the cells,future of medicine is immunotherapy.I congratulate you ,this branch ,you study is future of treatments in medicine.natural killer cells,macrophages,and etc...
Kasra jan, I don't know about the future, I just know that most of the immunologists I know are out of job today. :D Unless they work within the academy or with autoimmune related areas in a hospital.

actually I am treating most of my patients with immunotherapy medications,like tumor necrosis factors,which actually have revolutionized medicine,they are very useful in cancerous patients and rheumatic diseases,or in other features of autoimmune diseases,like lupus,and some blood disorders like lymphoma.....the only problem is they predispose you to get severe infection,especially tuberculosis,septic shock and etc.....
That's very interesting. I didn't know that. :) What kind of patients do you usually have? Cancerous? What kinds of TNFs do you use?
 

kasra1930

National Team Player
Dec 30, 2011
5,381
361
#20
Kasra jan, I don't know about the future, I just know that most of the immunologists I know are out of job today. :D Unless they work within the academy or with autoimmune related areas in a hospital.


That's very interesting. I didn't know that. :) What kind of patients do you usually have? Cancerous? What kinds of TNFs do you use?
sly jan,I have 3 different speciality and subspeciality.I am specialist in internal medicine(which covers all organs in the body example,heart lung ,stomach and etc),and subspecialist in Rheumatology(rheumatic diseases,arthritis),and also oncology(cancer specialist),.I graduated at yale-university school of medicine(USA),then I did my advanced Rheumatology at HARVARD university school of medicine...I am teaching to medical students now,and work with them daily in USA....

2)I use mostly Rituxan which is anti CD 20 inhibitors for treatment of lymphoma(which is lympn nodes cancer) and infliximab(which is anti tumor necrosis factor inhibitor) and humira(which is also another tumor necrosis factor),these are used in treatment of Rheumatoid arthritis,and some other rheumatic diseases that induce a very stiff back in medical term is called(Ankylosing spondylitis)....

3)yes you are right,immunologists, do not get enough money,but what about labratory medicine? especially after finishing university,you can open an office and get the money!! do you agree with it? what about you,tell me a little bit about yourself,it seems you are very smart....you know I am dealing with students,I can read who is smart and who is not,from your information and writing you provided to me,I can see you are very smart and enthusiastic.......................:--biggrin:--biggrin